Everolimus (RAD001) inhibits the proliferation of rat vascular smooth muscle cells by up-regulating the activity of the p27/kip1 gene promoter

OBJECTIVE: We investigated whether the inhibitory effect of the immunosuppressant everolimus (RAD001) on vascular smooth muscle cell (VSMC) proliferation is mediated by p27/kip1 gene promoter activity. METHODS: In this experimental study, cultured rat VSMCs were transiently transfected with a recomb...

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Detalles Bibliográficos
Autores principales: Ran, Boli, Li, Minfeng, Li, Yeqing, Lin, Yang, Liu, Weimin, Luo, Qiulin, Fu, Yongxin, Tang, Qianmei, Yang, Ya, Pu, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331368/
https://www.ncbi.nlm.nih.gov/pubmed/27163533
http://dx.doi.org/10.14744/AnatolJCardiol.2015.6426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331368/
https://www.ncbi.nlm.nih.gov/pubmed/27163533
http://dx.doi.org/10.14744/AnatolJCardiol.2015.6426

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