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Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER

Folding of proteins entering the secretory pathway in mammalian cells frequently requires the insertion of disulfide bonds. Disulfide insertion can result in covalent linkages found in the native structure as well as those that are not, so‐called non‐native disulfides. The pathways for disulfide for...

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Detalles Bibliográficos
Autores principales: Poet, Greg J, Oka, Ojore BV, van Lith, Marcel, Cao, Zhenbo, Robinson, Philip J, Pringle, Marie Anne, Arnér, Elias SJ, Bulleid, Neil J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331760/
https://www.ncbi.nlm.nih.gov/pubmed/28093500
http://dx.doi.org/10.15252/embj.201695336