Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure

BACKGROUND—: Hyaluronan (HA) is required for endothelial-to-mesenchymal transition and normal heart development in the mouse. Heart abnormalities in hyaluronidase 2 (HYAL2)–deficient (Hyal2(−)(/−)) mice and humans suggested removal of HA is also important for normal heart development. We have perfor...

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Detalles Bibliográficos
Autores principales: Chowdhury, Biswajit, Xiang, Bo, Liu, Michelle, Hemming, Richard, Dolinsky, Vernon W., Triggs-Raine, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331876/
https://www.ncbi.nlm.nih.gov/pubmed/28196902
http://dx.doi.org/10.1161/CIRCGENETICS.116.001598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331876/
https://www.ncbi.nlm.nih.gov/pubmed/28196902
http://dx.doi.org/10.1161/CIRCGENETICS.116.001598

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