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Safety evaluation of a vaccine: Effect in maternal reproductive outcome and fetal anomaly frequency in rats using a leishmanial vaccine as a model
While the immunogenic potential of the vaccination against infectious diseases was extensively shown, data on the safety assessment of recombinant proteins in vaccine formulations administered during pregnancy are still scarce. In the current study, the antigenicity of a vaccine against leishmaniasi...
Autores principales: | Moraes-Souza, Rafaianne Q., Reinaque, Ana Paula, Soares, Thaigra S., Silva, Ana Luiza T., Giunchetti, Rodolfo C., Takano, Maria A. S., Akamatsu, Milena A., Kubrusly, Flávia S., Lúcio-Macarini, Fernanda, Raw, Isaias, Iourtov, Dmitri, Ho, Paulo Lee, Bueno, Lilian L., Fujiwara, Ricardo T., Volpato, Gustavo T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332059/ https://www.ncbi.nlm.nih.gov/pubmed/28249007 http://dx.doi.org/10.1371/journal.pone.0172525 |
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