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Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes

In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital organs. Heparin can reverse the underlying ligand-recepto...

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Detalles Bibliográficos
Autores principales: Saiwaew, Somporn, Sritabal, Juntima, Piaraksa, Nattaporn, Keayarsa, Srisuda, Ruengweerayut, Ronnatrai, Utaisin, Chirapong, Sila, Patima, Niramis, Rangsan, Udomsangpetch, Rachanee, Charunwatthana, Prakaykaew, Pongponratn, Emsri, Pukrittayakamee, Sasithon, Leitgeb, Anna M., Wahlgren, Mats, Lee, Sue J., Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Chotivanich, Kesinee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332063/
https://www.ncbi.nlm.nih.gov/pubmed/28249043
http://dx.doi.org/10.1371/journal.pone.0172718