Stabilization of HIF-1α and HIF-2α, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model

Recently, we described a new animal model of CNS primitive neuroectodermal tumors (CNS-PNET), which was generated by orthotopic transplantation of human Radial Glial (RG) cells into NOD-SCID mice’s brain sub-ventricular zone. In the current study we conducted comprehensive RNA-Seq analyses to gain i...

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Detalles Bibliográficos
Autores principales: Malchenko, Sergey, Sredni, Simone Treiger, Bi, Yingtao, Margaryan, Naira V., Boyineni, Jerusha, Mohanam, Indra, Tomita, Tadanori, Davuluri, Ramana V., Soares, Marcelo B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332108/
https://www.ncbi.nlm.nih.gov/pubmed/28249000
http://dx.doi.org/10.1371/journal.pone.0173106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332108/
https://www.ncbi.nlm.nih.gov/pubmed/28249000
http://dx.doi.org/10.1371/journal.pone.0173106

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