Transcriptional Signature of an Altered Purine Metabolism in the Skeletal Muscle of a Huntington's Disease Mouse Model

Huntington's disease (HD) is a fatal neurodegenerative disorder, caused by a polyglutamine expansion in the huntingtin protein (HTT). HD has a peripheral component to its pathology: skeletal muscles are severely affected, leading to atrophy, and malfunction in both pre-clinical and clinical set...

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Detalles Bibliográficos
Autores principales: Mielcarek, Michal, Smolenski, Ryszard T., Isalan, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332388/
https://www.ncbi.nlm.nih.gov/pubmed/28303108
http://dx.doi.org/10.3389/fphys.2017.00127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332388/
https://www.ncbi.nlm.nih.gov/pubmed/28303108
http://dx.doi.org/10.3389/fphys.2017.00127

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