The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

Base excision repair (BER) may become less effective with ageing resulting in accumulation of DNA lesions, genome instability and altered gene expression that contribute to age-related degenerative diseases. The brain is particularly vulnerable to the accumulation of DNA lesions; hence, proper funct...

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Detalles Bibliográficos
Autores principales: Langie, Sabine A. S., Cameron, Kerry M., Ficz, Gabriella, Oxley, David, Tomaszewski, Bartłomiej, Gorniak, Joanna P., Maas, Lou M., Godschalk, Roger W. L., van Schooten, Frederik J., Reik, Wolf, von Zglinicki, Thomas, Mathers, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333064/
https://www.ncbi.nlm.nih.gov/pubmed/28218666
http://dx.doi.org/10.3390/genes8020075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333064/
https://www.ncbi.nlm.nih.gov/pubmed/28218666
http://dx.doi.org/10.3390/genes8020075

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