Targeting MDM4 Splicing in Cancers

MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Bardot, Boris, Toledo, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333071/
https://www.ncbi.nlm.nih.gov/pubmed/28230750
http://dx.doi.org/10.3390/genes8020082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333071/
https://www.ncbi.nlm.nih.gov/pubmed/28230750
http://dx.doi.org/10.3390/genes8020082

Ejemplares similares