NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A Virus

Post-translational modifications of viral proteins play important roles in regulating viral replication. Here we demonstrated that the PB2 of influenza A virus (IAV) can be modified by NEDD8. We revealed that E3 ligase HDM2 can promote PB2 NEDDylation. Overexpression of either NEDD8 or HDM2 can inhi...

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Detalles Bibliográficos
Autores principales: Zhang, Tinghong, Ye, Zhen, Yang, Xiaohai, Qin, Yujie, Hu, Yi, Tong, Xiaomei, Lai, Wenbin, Ye, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333077/
https://www.ncbi.nlm.nih.gov/pubmed/28252002
http://dx.doi.org/10.1038/srep43691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333077/
https://www.ncbi.nlm.nih.gov/pubmed/28252002
http://dx.doi.org/10.1038/srep43691

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