Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these double alterations remain unclear. Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is upreg...

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Detalles Bibliográficos
Autores principales: Ju, Huai-Qiang, Ying, Haoqiang, Tian, Tian, Ling, Jianhua, Fu, Jie, Lu, Yu, Wu, Min, Yang, Lifeng, Achreja, Abhinav, Chen, Gang, Zhuang, Zhuonan, Wang, Huamin, Nagrath, Deepak, Yao, Jun, Hung, Mien-Chie, DePinho, Ronald A., Huang, Peng, Xu, Rui-Hua, Chiao, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333128/
https://www.ncbi.nlm.nih.gov/pubmed/28232723
http://dx.doi.org/10.1038/ncomms14437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333128/
https://www.ncbi.nlm.nih.gov/pubmed/28232723
http://dx.doi.org/10.1038/ncomms14437

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