In silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressure

BACKGROUND: Cis-regulatory sequences are often composed of many low-affinity transcription factor binding sites (TFBSs). Determining the evolutionary and functional importance of regulatory sequence composition is impeded without a detailed knowledge of the genotype-phenotype map. RESULTS: We simula...

Descripción completa

Detalles Bibliográficos
Autores principales: Chertkova, Aleksandra A., Schiffman, Joshua S., Nuzhdin, Sergey V., Kozlov, Konstantin N., Samsonova, Maria G., Gursky, Vitaly V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333172/
https://www.ncbi.nlm.nih.gov/pubmed/28251865
http://dx.doi.org/10.1186/s12862-016-0866-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333172/
https://www.ncbi.nlm.nih.gov/pubmed/28251865
http://dx.doi.org/10.1186/s12862-016-0866-y

Ejemplares similares