The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) has one of the poorest survival rates among cancers. Using multi-regional sampling of nine resected HCC with different aetiologies, here we construct phylogenetic relationships of these sectors, showing diverse levels of genetic sharing, spanning early to late diversif...

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Detalles Bibliográficos
Autores principales: Zhai, Weiwei, Lim, Tony Kiat-Hon, Zhang, Tong, Phang, Su-Ting, Tiang, Zenia, Guan, Peiyong, Ng, Ming-Hwee, Lim, Jia Qi, Yao, Fei, Li, Zheng, Ng, Poh Yong, Yan, Jie, Goh, Brian K., Chung, Alexander Yaw-Fui, Choo, Su-Pin, Khor, Chiea Chuen, Soon, Wendy Wei-Jia, Sung, Ken Wing-Kin, Foo, Roger Sik-Yin, Chow, Pierce Kah-Hoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333358/
https://www.ncbi.nlm.nih.gov/pubmed/28240289
http://dx.doi.org/10.1038/ncomms14565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333358/
https://www.ncbi.nlm.nih.gov/pubmed/28240289
http://dx.doi.org/10.1038/ncomms14565

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