Cargando…

Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci

Detailed analyses of transcriptome have revealed complexity in regulation of alternative splicing (AS). These AS events often undergo modulation by genetic variants. Here we analyse RNA-sequencing data of prefrontal cortex from 206 individuals in combination with their genotypes and identify cis-act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takata, Atsushi, Matsumoto, Naomichi, Kato, Tadafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333373/ https://www.ncbi.nlm.nih.gov/pubmed/28240266 http://dx.doi.org/10.1038/ncomms14519

Ejemplares similares

Genome-Wide Identification of Splicing Quantitative Trait Loci (sQTLs) in Diverse Ecotypes of Arabidopsis thaliana
por: Khokhar, Waqas, et al.
Publicado: (2019)

CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer
por: Tian, Jianbo, et al.
Publicado: (2019)

Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart
por: Koopmann, Tamara T., et al.
Publicado: (2014)

Genome-wide Identification and Analysis of Splicing QTLs in Multiple Sclerosis by RNA-Seq Data
por: He, Yijie, et al.
Publicado: (2021)

Regional Variation of Splicing QTLs in Human Brain
por: Zhang, Yida, et al.
Publicado: (2020)

A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
por: Melzer, David, et al.
Publicado: (2008)

Methylation quantitative trait loci in the developing brain and their enrichment in schizophrenia-associated genomic regions
por: Hannon, Eilis, et al.
Publicado: (2015)

Genome-wide identification of tandem repeats associated with splicing variation across 49 tissues in humans
por: Hamanaka, Kohei, et al.
Publicado: (2023)

Genome-Wide Association Study of Schizophrenia in Japanese Population
por: Yamada, Kazuo, et al.
Publicado: (2011)

Identification of region-specific splicing QTLs in human hippocampal tissue and its distinctive role in brain disorders
por: Li, Xiaoyan, et al.
Publicado: (2023)

Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
por: Perzel Mandell, Kira A., et al.
Publicado: (2021)

Identification of Susceptible Loci and Enriched Pathways for Bipolar II Disorder Using Genome-Wide Association Studies
por: Kao, Chung-Feng, et al.
Publicado: (2016)

Alternative Splicing QTLs in European and African Populations
por: Ongen, Halit, et al.
Publicado: (2015)

The Future is The Past: Methylation QTLs in Schizophrenia
por: Hoffmann, Anke, et al.
Publicado: (2016)

No Evidence for Enrichment in Schizophrenia for Common Allelic Associations at Imprinted Loci
por: Escott-Price, Valentina, et al.
Publicado: (2015)

Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci
por: Davis, Lea K, et al.
Publicado: (2012)

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
por: Huan, Tianxiao, et al.
Publicado: (2019)

Genome-wide human brain eQTLs: In-depth analysis and insights using the UKBEC dataset
por: Sng, Letitia M. F., et al.
Publicado: (2019)

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci
por: Carnes, Megan Ulmer, et al.
Publicado: (2023)

Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs
por: Below, Jennifer E., et al.
Publicado: (2016)

Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
por: Ripke, Stephan, et al.
Publicado: (2013)

Genome wide association study identifies four loci for early onset schizophrenia
por: Guo, Suqin, et al.
Publicado: (2021)

Human Expression QTLs Are Enriched in Signals of Environmental Adaptation
por: Ye, Kaixiong, et al.
Publicado: (2013)

A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype
por: Hass, Johanna, et al.
Publicado: (2013)

Genome-wide identification of loci associated with growth in rainbow trout
por: Ali, Ali, et al.
Publicado: (2020)

Study of Quantitative Trait Loci (QTLs) Associated with Allelopathic Trait in Rice
por: Chung, Ill-Min, et al.
Publicado: (2020)

Systematic visualisation of molecular QTLs reveals variant mechanisms at GWAS loci
por: Kerimov, Nurlan, et al.
Publicado: (2023)

Genome-wide analysis of expression quantitative trait loci (eQTLs) reveals the regulatory architecture of gene expression variation in the storage roots of sweet potato
por: Zhang, Lei, et al.
Publicado: (2020)

Identification of eQTLs and sQTLs associated with meat quality in beef
por: Leal-Gutiérrez, Joel D., et al.
Publicado: (2020)

Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome
por: Garrido-Martín, Diego, et al.
Publicado: (2021)

Genome-wide identification of alternative splicing and splicing regulated in immune infiltration in osteosarcoma patients
por: Dai, Zhibing, et al.
Publicado: (2023)

Author Correction: Genome-wide human brain eQTLs: In-depth analysis and insights using the UKBEC dataset
por: Sng, Letitia M. F., et al.
Publicado: (2020)

Systematic identification of phenotypically enriched loci using a patient network of genomic disorders
por: Reyes-Palomares, Armando, et al.
Publicado: (2016)

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci
por: Børglum, A D, et al.
Publicado: (2014)

Recurrent NUS1 canonical splice donor site mutation in two unrelated individuals with epilepsy, myoclonus, ataxia and scoliosis - a case report
por: Den, Kouhei, et al.
Publicado: (2019)

Genome-wide eQTLs and heritability for gene expression traits in unrelated individuals
por: Yang, Shengjie, et al.
Publicado: (2014)

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci
por: Rahmioglu, Nilufer, et al.
Publicado: (2015)

Genome-wide Identification of Zero Nucleotide Recursive Splicing in Drosophila
por: Duff, Michael O., et al.
Publicado: (2015)

Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review
por: Corva, Pablo M, et al.
Publicado: (2001)

Genome-wide Identification of microRNA Expression Quantitative Trait Loci
por: Huan, Tianxiao, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_4v18jf3apsf27su1r1daol708b