Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest

The cis-stilbene, combretastatin A4 (CA4), is a potent microtubule targeting and vascular damaging agent. Despite promising results at the pre-clinical level and extensive clinical evaluation, CA4 has yet to be approved for therapeutic use. One impediment to the development of CA4 is an inherent con...

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Detalles Bibliográficos
Autores principales: Tarade, Daniel, Ma, Dennis, Pignanelli, Christopher, Mansour, Fadi, Simard, Daniel, van den Berg, Sean, Gauld, James, McNulty, James, Pandey, Siyaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333808/
https://www.ncbi.nlm.nih.gov/pubmed/28253265
http://dx.doi.org/10.1371/journal.pone.0171806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333808/
https://www.ncbi.nlm.nih.gov/pubmed/28253265
http://dx.doi.org/10.1371/journal.pone.0171806

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