Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

A set of chemical reactions that require a metabolite to synthesize more of that metabolite is an autocatalytic cycle. Here, we show that most of the reactions in the core of central carbon metabolism are part of compact autocatalytic cycles. Such metabolic designs must meet specific conditions to s...

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Detalles Bibliográficos
Autores principales: Barenholz, Uri, Davidi, Dan, Reznik, Ed, Bar-On, Yinon, Antonovsky, Niv, Noor, Elad, Milo, Ron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333975/
https://www.ncbi.nlm.nih.gov/pubmed/28169831
http://dx.doi.org/10.7554/eLife.20667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333975/
https://www.ncbi.nlm.nih.gov/pubmed/28169831
http://dx.doi.org/10.7554/eLife.20667

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