Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies

The P2X7 receptor (P2X7R) is important in mediating a range of physiological functions and pathologies associated with tissue damage and inflammation and represents an attractive therapeutic target. However, in terms of their structure-function relationships, the mammalian P2X7Rs remain poorly chara...

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Detalles Bibliográficos
Autores principales: Caseley, Emily A, Muench, Stephen P, Jiang, Lin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334206/
https://www.ncbi.nlm.nih.gov/pubmed/28025718
http://dx.doi.org/10.1007/s11302-016-9553-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334206/
https://www.ncbi.nlm.nih.gov/pubmed/28025718
http://dx.doi.org/10.1007/s11302-016-9553-0

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