The genetic background of acromegaly
Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334425/ https://www.ncbi.nlm.nih.gov/pubmed/28161730 http://dx.doi.org/10.1007/s11102-017-0789-7 |
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author | Gadelha, Mônica R. Kasuki, Leandro Korbonits, Márta |
author_facet | Gadelha, Mônica R. Kasuki, Leandro Korbonits, Márta |
author_sort | Gadelha, Mônica R. |
collection | PubMed |
description | Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotropinomas. This short review concentrates on the current knowledge of the genetic basis of both familial and sporadic acromegaly. |
format | Online Article Text |
id | pubmed-5334425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-53344252017-03-15 The genetic background of acromegaly Gadelha, Mônica R. Kasuki, Leandro Korbonits, Márta Pituitary Article Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotropinomas. This short review concentrates on the current knowledge of the genetic basis of both familial and sporadic acromegaly. Springer US 2017-02-04 2017 /pmc/articles/PMC5334425/ /pubmed/28161730 http://dx.doi.org/10.1007/s11102-017-0789-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Gadelha, Mônica R. Kasuki, Leandro Korbonits, Márta The genetic background of acromegaly |
title | The genetic background of acromegaly |
title_full | The genetic background of acromegaly |
title_fullStr | The genetic background of acromegaly |
title_full_unstemmed | The genetic background of acromegaly |
title_short | The genetic background of acromegaly |
title_sort | genetic background of acromegaly |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334425/ https://www.ncbi.nlm.nih.gov/pubmed/28161730 http://dx.doi.org/10.1007/s11102-017-0789-7 |
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