The genetic background of acromegaly

Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in...

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Autores principales: Gadelha, Mônica R., Kasuki, Leandro, Korbonits, Márta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334425/
https://www.ncbi.nlm.nih.gov/pubmed/28161730
http://dx.doi.org/10.1007/s11102-017-0789-7
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author Gadelha, Mônica R.
Kasuki, Leandro
Korbonits, Márta
author_facet Gadelha, Mônica R.
Kasuki, Leandro
Korbonits, Márta
author_sort Gadelha, Mônica R.
collection PubMed
description Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotropinomas. This short review concentrates on the current knowledge of the genetic basis of both familial and sporadic acromegaly.
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spelling pubmed-53344252017-03-15 The genetic background of acromegaly Gadelha, Mônica R. Kasuki, Leandro Korbonits, Márta Pituitary Article Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotropinomas. This short review concentrates on the current knowledge of the genetic basis of both familial and sporadic acromegaly. Springer US 2017-02-04 2017 /pmc/articles/PMC5334425/ /pubmed/28161730 http://dx.doi.org/10.1007/s11102-017-0789-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Gadelha, Mônica R.
Kasuki, Leandro
Korbonits, Márta
The genetic background of acromegaly
title The genetic background of acromegaly
title_full The genetic background of acromegaly
title_fullStr The genetic background of acromegaly
title_full_unstemmed The genetic background of acromegaly
title_short The genetic background of acromegaly
title_sort genetic background of acromegaly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334425/
https://www.ncbi.nlm.nih.gov/pubmed/28161730
http://dx.doi.org/10.1007/s11102-017-0789-7
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