Accelerated aging exacerbates a pre‐existing pathology in a tau transgenic mouse model

Age is a critical factor in the prevalence of tauopathies, including Alzheimer's disease. To observe how an aging phenotype interacts with and affects the pathological intracellular accumulation of hyperphosphorylated tau, the tauopathy mouse model pR5 (expressing P301L mutant human tau) was ba...

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Detalles Bibliográficos
Autores principales: Bodea, Liviu‐Gabriel, Evans, Harrison Tudor, Van der Jeugd, Ann, Ittner, Lars M., Delerue, Fabien, Kril, Jillian, Halliday, Glenda, Hodges, John, Kiernan, Mathew C., Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334525/
https://www.ncbi.nlm.nih.gov/pubmed/28160413
http://dx.doi.org/10.1111/acel.12565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334525/
https://www.ncbi.nlm.nih.gov/pubmed/28160413
http://dx.doi.org/10.1111/acel.12565

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