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Homocysteine modulates 5‐lipoxygenase expression level via DNA methylation

Elevated levels of homocysteinemia (Hcy), a risk factor for late‐onset Alzheimer's disease (AD), have been associated with changes in cell methylation. Alzheimer's disease is characterized by an upregulation of the 5‐lipoxygenase (5LO), whose promoter is regulated by methylation. However,...

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Detalles Bibliográficos
Autores principales: Li, Jian‐Guo, Barrero, Carlos, Gupta, Sapna, Kruger, Warren D., Merali, Salim, Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334532/
https://www.ncbi.nlm.nih.gov/pubmed/27896923
http://dx.doi.org/10.1111/acel.12550