A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice

New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in depressed patients but also side effects that complicate its clinical utility. Ketamine promotes excitatory synaptic strength...

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Detalles Bibliográficos
Autores principales: Zanos, Panos, Nelson, Mackenzie E., Highland, Jaclyn N., Krimmel, Samuel R., Georgiou, Polymnia, Gould, Todd D., Thompson, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334634/
https://www.ncbi.nlm.nih.gov/pubmed/28275719
http://dx.doi.org/10.1523/ENEURO.0285-16.2017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334634/
https://www.ncbi.nlm.nih.gov/pubmed/28275719
http://dx.doi.org/10.1523/ENEURO.0285-16.2017

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