Cargando…

A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice

New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in depressed patients but also side effects that complicate its clinical utility. Ketamine promotes excitatory synaptic strength...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zanos, Panos, Nelson, Mackenzie E., Highland, Jaclyn N., Krimmel, Samuel R., Georgiou, Polymnia, Gould, Todd D., Thompson, Scott M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2017
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334634/ https://www.ncbi.nlm.nih.gov/pubmed/28275719 http://dx.doi.org/10.1523/ENEURO.0285-16.2017

Ejemplares similares

Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation
por: Georgiou, Polymnia, et al.
Publicado: (2019)

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action
por: Aleksandrova, Lily R., et al.
Publicado: (2017)

NMDAR inhibition-independent antidepressant actions of ketamine metabolites
por: Zanos, Panos, et al.
Publicado: (2016)

Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine
por: Tarrés-Gatius, Mireia, et al.
Publicado: (2020)

Allosteric Site Mediates Inhibition of Tonic NMDA Receptor Activity by Low Dose Ketamine
por: Popescu, Gabriela, et al.
Publicado: (2023)

Ketamine may block NMDA receptors in astrocytes causing a rapid antidepressant effect
por: Mitterauer, Bernhard J.
Publicado: (2012)

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects
por: Li, S-X, et al.
Publicado: (2018)

Announcing the novel class of GABA–A receptor selective positive allosteric modulator antidepressants
por: Fasipe, Olumuyiwa John, et al.
Publicado: (2020)

Allosteric Inhibitors of NMDA Receptor Functions
por: Popescu, Gabriela K., et al.
Publicado: (2010)

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
por: France, G., et al.
Publicado: (2022)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

Allosteric antagonist action at triheteromeric NMDA receptors
por: Gibb, Alasdair J.
Publicado: (2022)

Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects
por: Burgdorf, Jeffrey S, et al.
Publicado: (2022)

Allosteric Modulation of αβδ GABA(A) Receptors
por: Feng, Hua-Jun
Publicado: (2010)

From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs: Closing the Circle?
por: Fernández-Teruel, Alberto
Publicado: (2022)

Post-weaning A1/A2 β-casein milk intake modulates depressive-like behavior, brain μ-opioid receptors, and the metabolome of rats
por: Osman, Aya, et al.
Publicado: (2021)

GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics
por: Bhandage, Amol K., et al.
Publicado: (2014)

Allosteric modulation of GABA(A) receptors by extracellular ATP
por: Liu, Jun, et al.
Publicado: (2014)

Emotional Impairment and Persistent Upregulation of mGlu(5) Receptor following Morphine Abstinence: Implications of an mGlu(5)-MOPr Interaction
por: Zanos, Panos, et al.
Publicado: (2016)

Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
por: Yao, Lulu, et al.
Publicado: (2017)

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
por: Ritter, Nadine, et al.
Publicado: (2023)

Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice
por: Tang, Juanjuan, et al.
Publicado: (2015)

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
por: Miller, Oliver H, et al.
Publicado: (2014)

Orthosteric- versus allosteric-dependent activation of the GABA(A) receptor requires numerically distinct subunit level rearrangements
por: Amin, Jahanshah, et al.
Publicado: (2017)

Antidepressant Interactions with the NMDA NR1-1b Subunit
por: Raabe, Richard, et al.
Publicado: (2008)

Cognitive Impairment That Is Induced by (R)-Ketamine Is Abolished in NMDA GluN2D Receptor Subunit Knockout Mice
por: Ide, Soichiro, et al.
Publicado: (2019)

Pregnanolone Glutamate, a Novel Use-Dependent NMDA Receptor Inhibitor, Exerts Antidepressant-Like Properties in Animal Models
por: Holubova, Kristina, et al.
Publicado: (2014)

Understanding subtype-selective allosteric modulation of GABA(A) receptors
por: Puthenkalam, Roshan, et al.
Publicado: (2012)

Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors
por: Li, Sijun, et al.
Publicado: (2023)

NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina
por: Bai, Ning, et al.
Publicado: (2013)

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
por: Piantadosi, Sean C., et al.
Publicado: (2016)

NMDA Receptor Antagonist Ketamine Impairs Feature Integration in Visual Perception
por: Meuwese, Julia D. I., et al.
Publicado: (2013)

PS126. DAPK1 interaction with NMDA receptor NR2B subunit underlies the rapid antidepressant effect
por: Xu, Ling-Zhi, et al.
Publicado: (2016)

α subunits in GABA(A) receptors are dispensable for GABA and diazepam action
por: Wongsamitkul, Nisa, et al.
Publicado: (2017)

Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine
por: Kalkman, Hans O.
Publicado: (2023)

Characterization of zebrafish GABA(A) receptor subunits
por: Sadamitsu, Kenichiro, et al.
Publicado: (2021)

Specific Roles of NMDA Receptor Subunits in Mental Disorders
por: Yamamoto, H., et al.
Publicado: (2015)

Cocaine-induced Changes in the Expression of NMDA Receptor Subunits
por: Smaga, Irena, et al.
Publicado: (2019)

Allosteric Modulators of GABA(B) Receptors: Mechanism of Action and Therapeutic Perspective
por: Pin, Jean-Philippe, et al.
Publicado: (2007)

Novel positive allosteric modulators of GABA(A) receptors with anesthetic activity
por: Maldifassi, Maria C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5nfuijp61aia1l7go14n6bpoct