Normalization and microbial differential abundance strategies depend upon data characteristics

BACKGROUND: Data from 16S ribosomal RNA (rRNA) amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeros. Although we are typically interested in comparing relative a...

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Detalles Bibliográficos
Autores principales: Weiss, Sophie, Xu, Zhenjiang Zech, Peddada, Shyamal, Amir, Amnon, Bittinger, Kyle, Gonzalez, Antonio, Lozupone, Catherine, Zaneveld, Jesse R., Vázquez-Baeza, Yoshiki, Birmingham, Amanda, Hyde, Embriette R., Knight, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335496/
https://www.ncbi.nlm.nih.gov/pubmed/28253908
http://dx.doi.org/10.1186/s40168-017-0237-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335496/
https://www.ncbi.nlm.nih.gov/pubmed/28253908
http://dx.doi.org/10.1186/s40168-017-0237-y

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