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Normalization and microbial differential abundance strategies depend upon data characteristics
BACKGROUND: Data from 16S ribosomal RNA (rRNA) amplicon sequencing present challenges to ecological and statistical interpretation. In particular, library sizes often vary over several ranges of magnitude, and the data contains many zeros. Although we are typically interested in comparing relative a...
Autores principales: | Weiss, Sophie, Xu, Zhenjiang Zech, Peddada, Shyamal, Amir, Amnon, Bittinger, Kyle, Gonzalez, Antonio, Lozupone, Catherine, Zaneveld, Jesse R., Vázquez-Baeza, Yoshiki, Birmingham, Amanda, Hyde, Embriette R., Knight, Rob |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335496/ https://www.ncbi.nlm.nih.gov/pubmed/28253908 http://dx.doi.org/10.1186/s40168-017-0237-y |
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