Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome, inhibit transcription and block replication. The primary enzyme that repairs AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base excision repair (BER) pathway. Although the...

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Detalles Bibliográficos
Autores principales: Roychoudhury, Shrabasti, Nath, Somsubhra, Song, Heyu, Hegde, Muralidhar L., Bellot, Larry J., Mantha, Anil K., Sengupta, Shiladitya, Ray, Sutapa, Natarajan, Amarnath, Bhakat, Kishor K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335514/
https://www.ncbi.nlm.nih.gov/pubmed/27994014
http://dx.doi.org/10.1128/MCB.00401-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335514/
https://www.ncbi.nlm.nih.gov/pubmed/27994014
http://dx.doi.org/10.1128/MCB.00401-16

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