Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation

Histone H3 lysine 36 methylation (H3K36me) is critical for epigenetic regulation and mutations at or near H3K36 are associated with distinct types of cancers. H3K36M dominantly inhibits H3K36me on wild-type histones, whereas H3G34R/V selectively affects H3K36me on the same histone tail. Here we repo...

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Detalles Bibliográficos
Autores principales: Zhang, Yinglu, Shan, Chun-Min, Wang, Jiyong, Bao, Kehan, Tong, Liang, Jia, Songtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335568/
https://www.ncbi.nlm.nih.gov/pubmed/28256625
http://dx.doi.org/10.1038/srep43906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335568/
https://www.ncbi.nlm.nih.gov/pubmed/28256625
http://dx.doi.org/10.1038/srep43906

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