Cargando…

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

Fibroblast growth factor 21 (FGF21) has emerged as an important beneficial regulator of glucose and lipid homeostasis but its levels are also abnormally increased in insulin-resistant states in rodents and humans. The synthetic retinoid Fenretinide inhibits obesity and improves glucose homeostasis i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morrice, Nicola, Mcilroy, George D., Tammireddy, Seshu R., Reekie, Jennifer, Shearer, Kirsty D., Doherty, Mary K., Delibegović, Mirela, Whitfield, Phillip D., Mody, Nimesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335663/ https://www.ncbi.nlm.nih.gov/pubmed/28256636 http://dx.doi.org/10.1038/srep43782

Ejemplares similares

Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus
por: Mcilroy, George D., et al.
Publicado: (2013)

Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
por: Mcilroy, George D., et al.
Publicado: (2016)

Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR(−/−) mice
por: Thompson, Dawn, et al.
Publicado: (2023)

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
por: Lees, Emma K, et al.
Publicado: (2014)

Neuronal human BACE1 knockin induces systemic diabetes in mice
por: Plucińska, Kaja, et al.
Publicado: (2016)

Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors
por: Bensa, Veronica, et al.
Publicado: (2021)

The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide
por: Carr, Amanda-Jayne, et al.
Publicado: (2011)

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice
por: Lees, Emma K., et al.
Publicado: (2017)

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
por: Hoggard, Nigel, et al.
Publicado: (2012)

Response to comment by Moxon et al.
por: Thompson, Dawn, et al.
Publicado: (2018)

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR(−/−) mouse model of atherosclerosis
por: Thompson, Dawn, et al.
Publicado: (2017)

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid: Relationship With Plasma FGF21 and Body Adiposity
por: Tan, Bee K., et al.
Publicado: (2011)

FGF19 subfamily members: FGF19 and FGF21
por: Dolegowska, Katarzyna, et al.
Publicado: (2019)

Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
por: Adams, Andrew C., et al.
Publicado: (2012)

Surviving Starvation: Proteomic and Lipidomic Profiling of Nutrient Deprivation in the Smallest Known Free-Living Eukaryote
por: Martin, Sarah F., et al.
Publicado: (2020)

FGF21 and Cardiac Physiopathology
por: Planavila, Anna, et al.
Publicado: (2015)

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
por: Villarroya, Joan, et al.
Publicado: (2018)

Combining a BCL2 Inhibitor with the Retinoid Derivative Fenretinide Targets Melanoma Cells Including Melanoma Initiating Cells
por: Mukherjee, Nabanita, et al.
Publicado: (2014)

FGF19 and FGF21: In NASH we trust
por: Talukdar, Saswata, et al.
Publicado: (2020)

Lower Cerebrospinal Fluid/Plasma Fibroblast Growth Factor 21 (FGF21) Ratios and Placental FGF21 Production in Gestational Diabetes
por: Tan, Bee K., et al.
Publicado: (2013)

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
por: Kim, Kook Hwan, et al.
Publicado: (2014)

FGF21 and the Physiological Regulation of Macronutrient Preference
por: Hill, Cristal M, et al.
Publicado: (2020)

Head Over Hepatocytes for FGF21
por: Potthoff, Matthew J., et al.
Publicado: (2014)

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human
por: Henriksson, Emma, et al.
Publicado: (2020)

Analysis of Functional Promoter of Camel FGF21 Gene and Identification of Small Compounds Targeting FGF21 Protein
por: Yong, Fang, et al.
Publicado: (2023)

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE(−/−) mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
por: Thompson, D., et al.
Publicado: (2017)

FGF21 contributes to neuroendocrine control of female reproduction
por: Owen, Bryn M., et al.
Publicado: (2013)

Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?
por: Uebanso, Takashi, et al.
Publicado: (2011)

Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels
por: Cuevas-Ramos, Daniel, et al.
Publicado: (2012)

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
por: Fisher, ffolliott M., et al.
Publicado: (2010)

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
por: Agrawal, Archita, et al.
Publicado: (2018)

Inventing new medicines: The FGF21 story()
por: Kharitonenkov, Alexei, et al.
Publicado: (2013)

The good, the bad, and the unknown: Fructose and FGF21()
por: Hofmann, Susanna M., et al.
Publicado: (2014)

Metabolic Effects of FGF-21: Thermoregulation and Beyond
por: Ni, Bin, et al.
Publicado: (2015)

FGF-21 levels in polyuria-polydipsia syndrome
por: Refardt, Julie, et al.
Publicado: (2018)

FGF21 Levels in Pheochromocytoma/Functional Paraganglioma
por: Klímová, Judita, et al.
Publicado: (2019)

FGF21 as Modulator of Metabolism in Health and Disease
por: Tezze, Caterina, et al.
Publicado: (2019)

The role of FGF21 in the pathogenesis of cardiovascular disease
por: Zhang, Ying, et al.
Publicado: (2021)

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms
por: Satoh, Aoi, et al.
Publicado: (2020)

Liver-brain axis with alcohol: Role of fibroblast growth factor 21 (FGF21)
por: Zhang, Ke, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ssv2jnbjt1junqk71cne9l15gm