The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive...

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Autores principales: Prosser, Gareth, Brandenburg, Julius, Reiling, Norbert, Barry, Clifton Earl, Wilkinson, Robert J., Wilkinson, Katalin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335906/
https://www.ncbi.nlm.nih.gov/pubmed/27780773
http://dx.doi.org/10.1016/j.micinf.2016.10.001
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author Prosser, Gareth
Brandenburg, Julius
Reiling, Norbert
Barry, Clifton Earl
Wilkinson, Robert J.
Wilkinson, Katalin A.
author_facet Prosser, Gareth
Brandenburg, Julius
Reiling, Norbert
Barry, Clifton Earl
Wilkinson, Robert J.
Wilkinson, Katalin A.
author_sort Prosser, Gareth
collection PubMed
description Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.
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spelling pubmed-53359062017-03-09 The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition Prosser, Gareth Brandenburg, Julius Reiling, Norbert Barry, Clifton Earl Wilkinson, Robert J. Wilkinson, Katalin A. Microbes Infect Article Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines. Elsevier 2017-03 /pmc/articles/PMC5335906/ /pubmed/27780773 http://dx.doi.org/10.1016/j.micinf.2016.10.001 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prosser, Gareth
Brandenburg, Julius
Reiling, Norbert
Barry, Clifton Earl
Wilkinson, Robert J.
Wilkinson, Katalin A.
The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
title The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
title_full The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
title_fullStr The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
title_full_unstemmed The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
title_short The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
title_sort bacillary and macrophage response to hypoxia in tuberculosis and the consequences for t cell antigen recognition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335906/
https://www.ncbi.nlm.nih.gov/pubmed/27780773
http://dx.doi.org/10.1016/j.micinf.2016.10.001
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