Cytotoxic effector functions of T cells are not required for protective immunity against fatal Rickettsia typhi infection in a murine model of infection: Role of T(H)1 and T(H)17 cytokines in protection and pathology

Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection. BALB/c wild-type mice generate CD4(+) T(H)1 and cytotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales: Moderzynski, Kristin, Heine, Liza, Rauch, Jessica, Papp, Stefanie, Kuehl, Svenja, Richardt, Ulricke, Fleischer, Bernhard, Osterloh, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336310/
https://www.ncbi.nlm.nih.gov/pubmed/28222146
http://dx.doi.org/10.1371/journal.pntd.0005404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336310/
https://www.ncbi.nlm.nih.gov/pubmed/28222146
http://dx.doi.org/10.1371/journal.pntd.0005404

Ejemplares similares