Sustained p16(INK4a) expression is required to prevent IR-induced tumorigenesis in mice

Exposure of murine and human tissues to ionizing radiation (IR) induces the expression of p16(INK4a), a tumor suppressor gene and senescence/aging biomarker. Increased p16(INK4a) expression is often delayed several weeks post exposure to IR. In this context, it remains unclear if it occurs to suppre...

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Detalles Bibliográficos
Autores principales: Palacio, L, Krishna, V, Le, NLO, Sharpless, NE, Beauséjour, CM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336385/
https://www.ncbi.nlm.nih.gov/pubmed/27568978
http://dx.doi.org/10.1038/onc.2016.298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336385/
https://www.ncbi.nlm.nih.gov/pubmed/27568978
http://dx.doi.org/10.1038/onc.2016.298

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