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Sustained p16(INK4a) expression is required to prevent IR-induced tumorigenesis in mice
Exposure of murine and human tissues to ionizing radiation (IR) induces the expression of p16(INK4a), a tumor suppressor gene and senescence/aging biomarker. Increased p16(INK4a) expression is often delayed several weeks post exposure to IR. In this context, it remains unclear if it occurs to suppre...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336385/ https://www.ncbi.nlm.nih.gov/pubmed/27568978 http://dx.doi.org/10.1038/onc.2016.298 |