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Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation

Membrane-integral pyrophosphatases (mPPases) couple the hydrolysis of pyrophosphate (PP(i)) to the pumping of Na(+), H(+), or both these ions across a membrane. Recently solved structures of the Na(+)-pumping Thermotoga maritima mPPase (TmPPase) and H(+)-pumping Vigna radiata mPPase revealed the bas...

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Detalles Bibliográficos
Autores principales: Shah, Nita R., Wilkinson, Craig, Harborne, Steven P. D., Turku, Ainoleena, Li, Kun-Mou, Sun, Yuh-Ju, Harris, Sarah, Goldman, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336470/
https://www.ncbi.nlm.nih.gov/pubmed/28345008
http://dx.doi.org/10.1063/1.4978038