Cargando…

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors were used in animal and clinical studies. Coversin (Ornithodoros moubata comp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pischke, Soeren E., Gustavsen, A., Orrem, H. L., Egge, K. H., Courivaud, F., Fontenelle, H., Despont, A., Bongoni, A. K., Rieben, R., Tønnessen, T. I., Nunn, M. A., Scott, H., Skulstad, H., Barratt-Due, A., Mollnes, T. E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336537/ https://www.ncbi.nlm.nih.gov/pubmed/28258298 http://dx.doi.org/10.1007/s00395-017-0610-9

Ejemplares similares

Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
por: Barratt-Due, Andreas, et al.
Publicado: (2016)

Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
por: Orrem, Hilde L., et al.
Publicado: (2018)

The Role of Complement in Liver Injury, Regeneration, and Transplantation
por: Thorgersen, Ebbe Billmann, et al.
Publicado: (2019)

Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets
por: Barratt-Due, Andreas, et al.
Publicado: (2017)

Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
por: Skjeflo, Espen W., et al.
Publicado: (2015)

Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus – When Incubated in Human Whole Blood
por: Medeiros, Pedro Miguel Coelho, et al.
Publicado: (2022)

Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
por: Gustavsen, Alice, et al.
Publicado: (2017)

Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
por: Hellerud, Bernt C., et al.
Publicado: (2017)

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
por: Orrem, Hilde L., et al.
Publicado: (2018)

Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
por: Jager, Neeltina M., et al.
Publicado: (2022)

Inflammatory stimuli induce shedding of heparan sulfate from arterial but not venous porcine endothelial cells leading to differential proinflammatory and procoagulant responses
por: Milusev, Anastasia, et al.
Publicado: (2023)

Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4–MD2 Complex
por: Gustavsen, Alice, et al.
Publicado: (2016)

Posterior fossa ependymoblastoma diagnosed in the second month of life: uneventful 12 years survival after gross total resection followed by chemotherapy
por: Due-Tønnessen, Bernt Johan, et al.
Publicado: (2015)

Neurosurgical treatment of brain tumors in the first 6 months of life: long-term follow-up of a single consecutive institutional series of 30 patients
por: Lundar, Tryggve, et al.
Publicado: (2015)

Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
por: Rydenfelt, Kristina, et al.
Publicado: (2023)

Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs
por: Kamat, Pranitha, et al.
Publicado: (2016)

Reduced Cardiac Function by Echocardiography in a Minority of COVID-19 Patients 3 Months after Hospitalization
por: Tangen, Jorun, et al.
Publicado: (2022)

Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis
por: Torp, M-K., et al.
Publicado: (2022)

Neurosurgical treatment of gangliogliomas in children and adolescents: long-term follow-up of a single-institution series of 32 patients
por: Lundar, Tryggve, et al.
Publicado: (2018)

Long-term outcome of posterior fossa medulloblastoma in patients surviving more than 20 years following primary treatment in childhood
por: Frič, Radek, et al.
Publicado: (2020)

Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model
por: Pischke, Soeren Erik, et al.
Publicado: (2019)

3D artificial round section micro-vessels to investigate endothelial cells under physiological flow conditions
por: Sfriso, Riccardo, et al.
Publicado: (2018)

Immunopathology of terminal complement activation and complement C5 blockade creating a pro‐survival and organ‐protective phenotype in trauma
por: Yang, Zhangsheng, et al.
Publicado: (2022)

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
por: Holter, Jan C., et al.
Publicado: (2020)

The alternative complement pathway revisited
por: Harboe, Morten, et al.
Publicado: (2008)

Postoperative radiotherapy for pediatric brain tumor: a lesson learned from treatment of a 5-year-old girl for posterior fossa astrocytoma (WHO1) in 1967
por: Lundar, Tryggve, et al.
Publicado: (2018)

Biomarkers for PVR in rhegmatogenous retinal detachment
por: Zandi, Souska, et al.
Publicado: (2019)

Posterior fossa ependymoma in childhood: 60 years event-free survival after partial resection—a case report
por: Lundar, Tryggve, et al.
Publicado: (2015)

Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood
por: Bongoni, Anjan K., et al.
Publicado: (2017)

Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
por: Rognes, Ingrid Nygren, et al.
Publicado: (2021)

Immediate Root Filling
por: Smith, H. A.
Publicado: (1888)

Immediate Root Filling
por: Smith, H. A.
Publicado: (1888)

A role for complement blockade in kidney transplantation
por: Karpman, Diana, et al.
Publicado: (2022)

COMPLEMENT AND COMPLEMENT-LIKE ACTIVITY IN LOWER VERTEBRATES AND INVERTEBRATES
por: Day, N. K. B., et al.
Publicado: (1970)

Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival
por: Witczak, Bartlomiej J., et al.
Publicado: (2021)

Outcomes in adulthood after neurosurgical treatment of brain tumors in the first 3 years of life: long-term follow-up of a single consecutive institutional series of 97 patients
por: Lundar, Tryggve, et al.
Publicado: (2020)

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway
por: Barratt, Jonathan, et al.
Publicado: (2021)

Complement blockade with eculizumab for treatment of severe Coronavirus Disease 2019 in pregnancy: A case series
por: Burwick, Richard M., et al.
Publicado: (2022)

Cytokines monitored by microdialysis detect rejection earlier than current methods in liver transplantation
por: Wælgaard, L, et al.
Publicado: (2007)

Editorial: The Role of Complement in Health and Disease
por: Cedzyński, Maciej, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3jrlh17qapjrjsq10jk1k4op5e