cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells

This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying mechanisms of the resulting increase in HDAC8 expression on cisplatin-induced apoptosis in lung cancer cells. c...

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Detalles Bibliográficos
Autores principales: Park, Ji-Yeon, Juhnn, Yong-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336561/
https://www.ncbi.nlm.nih.gov/pubmed/28232663
http://dx.doi.org/10.1038/emm.2016.152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336561/
https://www.ncbi.nlm.nih.gov/pubmed/28232663
http://dx.doi.org/10.1038/emm.2016.152

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