The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4(+) T cells

Therapeutic tolerance to self-antigens or foreign antigens is thought to depend on constant vigilance by Foxp3(+) regulatory T cells (Tregs). Previous work using a pancreatic islet allograft model and a short pulse of CD3 antibody therapy has shown that CD8(+) T cells become anergic and use TGFβ and...

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Detalles Bibliográficos
Autores principales: Besançon, Alix, Baas, Marije, Goncalves, Tania, Valette, Fabrice, Waldmann, Herman, Chatenoud, Lucienne, You, Sylvaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337867/
https://www.ncbi.nlm.nih.gov/pubmed/28321218
http://dx.doi.org/10.3389/fimmu.2017.00218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337867/
https://www.ncbi.nlm.nih.gov/pubmed/28321218
http://dx.doi.org/10.3389/fimmu.2017.00218

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