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PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide
Lipids are the primary components of the skin permeability barrier, which is the body's most powerful defensive mechanism against pathogens. Acylceramide (ω-O-acylceramide) is a specialized lipid essential for skin barrier formation. Here, we identify PNPLA1 as the long-sought gene involved in...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337975/ https://www.ncbi.nlm.nih.gov/pubmed/28248318 http://dx.doi.org/10.1038/ncomms14610 |