Cargando…

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2(neg) T cells, implicated in responses to viral infection and cancer. The prevale...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davey, Martin S., Willcox, Carrie R., Joyce, Stephen P., Ladell, Kristin, Kasatskaya, Sofya A., McLaren, James E., Hunter, Stuart, Salim, Mahboob, Mohammed, Fiyaz, Price, David A., Chudakov, Dmitriy M., Willcox, Benjamin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337994/ https://www.ncbi.nlm.nih.gov/pubmed/28248310 http://dx.doi.org/10.1038/ncomms14760

Ejemplares similares

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations
por: Hunter, Stuart, et al.
Publicado: (2018)

The human Vδ2(+) T-cell compartment comprises distinct innate-like Vγ9(+) and adaptive Vγ9(-) subsets
por: Davey, Martin S., et al.
Publicado: (2018)

γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
por: Willcox, Benjamin E., et al.
Publicado: (2020)

Development and Selection of the Human Vγ9Vδ2(+) T-Cell Repertoire
por: Willcox, Carrie R., et al.
Publicado: (2018)

Human γδ TCR Repertoires in Health and Disease
por: Fichtner, Alina Suzann, et al.
Publicado: (2020)

Recasting Human Vδ1 Lymphocytes in an Adaptive Role
por: Davey, Martin S., et al.
Publicado: (2018)

Vδ2(+) T Cells—Two Subsets for the Price of One
por: Davey, Martin S., et al.
Publicado: (2018)

Butyrophilin-like 3 Directly Binds a Human Vγ4(+) T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen
por: Willcox, Carrie R., et al.
Publicado: (2019)

Huge Overlap of Individual TCR Beta Repertoires
por: Shugay, Mikhail, et al.
Publicado: (2013)

Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
por: Degirmencay, Abdullah, et al.
Publicado: (2023)

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing
por: Karunakaran, Mohindar M., et al.
Publicado: (2020)

Identification of the Ligands of TCRγδ by Screening the Immune Repertoire of γδT Cells From Patients With Tuberculosis
por: Li, Yuxia, et al.
Publicado: (2019)

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection
por: Salim, Mahboob, et al.
Publicado: (2016)

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging
por: Egorov, Evgeny S., et al.
Publicado: (2018)

Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System
por: Yokosuka, Tadashi, et al.
Publicado: (2002)

Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells
por: Karunakaran, Mohindar Murugesh, et al.
Publicado: (2023)

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells
por: Pearson, James A., et al.
Publicado: (2016)

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging
por: Kallemeijn, Martine J., et al.
Publicado: (2018)

Evaluation of the TCR Repertoire as a Predictive and Prognostic Biomarker in Cancer: Diversity or Clonality?
por: Aran, Andrea, et al.
Publicado: (2022)

A discrete chromatin loop in the murine Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires
por: Chen, Liang, et al.
Publicado: (2015)

A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing
por: Karunakaran, Mohindar M., et al.
Publicado: (2023)

Secondary structure and (1)H, (13)C and (15)N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression
por: Salim, M., et al.
Publicado: (2016)

Bordeaux 2018: Wine, Cheese, and γδ T Cells
por: Edelblum, Karen, et al.
Publicado: (2019)

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells
por: Terrence, Kathleen, et al.
Publicado: (2000)

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023)

tcR: an R package for T cell receptor repertoire advanced data analysis
por: Nazarov, Vadim I., et al.
Publicado: (2015)

Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
por: Neller, Michelle A, et al.
Publicado: (2015)

Suppressive activity of Vδ2(+) γδ T cells on αβ T cells is licensed by TCR signaling and correlates with signal strength
por: Schilbach, Karin, et al.
Publicado: (2020)

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A
por: Howson, Lauren J., et al.
Publicado: (2018)

Clonal Distribution and Intratumor Heterogeneity of the TCR Repertoire in Papillary Thyroid Cancer With or Without Coexistent Hashimoto’s Thyroiditis
por: Cui, Likun, et al.
Publicado: (2022)

CD4(+) T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4(+) Cells
por: Brenna, Elena, et al.
Publicado: (2020)

Gene expression pattern of TCR repertoire and alteration expression of IL-17A gene of γδ T cells in patients with acute myocardial infarction
por: Chen, Xiao-ming, et al.
Publicado: (2018)

Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2013)

Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program
por: McMurray, Jack L., et al.
Publicado: (2022)

Regulation of TCR δ and α repertoires by local and long-distance control of variable gene segment chromatin structure
por: Hawwari, Abbas, et al.
Publicado: (2005)

Successful treatment of a pure red-cell aplasia patient with γδT cells and clonal TCR gene rearrangement: A case report
por: Li, Xian, et al.
Publicado: (2023)

RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy
por: Zhigalova, Ekaterina A., et al.
Publicado: (2020)

Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for presentation of transformed self
por: Mohammed, Fiyaz, et al.
Publicado: (2008)

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells
por: Sumaria, Nital, et al.
Publicado: (2017)

Selective activation of TCR-γδ(+ )cells in endemic Burkitt's lymphoma
por: Futagbi, Godfred, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ipne1fktib7i4lvjbjjk4lktg1