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A 3D self-organizing multicellular epidermis model of barrier formation and hydration with realistic cell morphology based on EPISIM

The epidermis and the stratum corneum (SC) as its outermost layer have evolved to protect the body from evaporative water loss to the environment. To morphologically represent the extremely flattened cells of the SC - and thereby the epidermal barrier - in a multicellular computational model, we dev...

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Detalles Bibliográficos
Autores principales: Sütterlin, Thomas, Tsingos, Erika, Bensaci, Jalil, Stamatas, Georgios N., Grabe, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338006/
https://www.ncbi.nlm.nih.gov/pubmed/28262741
http://dx.doi.org/10.1038/srep43472