Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors

The neural precursor cell expressed developmentally down-regulated gene 4–2, Nedd4-2, is an epilepsy-associated gene with at least three missense mutations identified in epileptic patients. Nedd4-2 encodes a ubiquitin E3 ligase that has high affinity toward binding and ubiquitinating membrane protei...

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Detalles Bibliográficos
Autores principales: Zhu, Jiuhe, Lee, Kwan Young, Jewett, Kathryn A., Man, Heng-Ye, Chung, Hee Jung, Tsai, Nien-Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338825/
https://www.ncbi.nlm.nih.gov/pubmed/28212375
http://dx.doi.org/10.1371/journal.pgen.1006634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338825/
https://www.ncbi.nlm.nih.gov/pubmed/28212375
http://dx.doi.org/10.1371/journal.pgen.1006634

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