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Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice

A long-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates neuroendocrine functions such as adrenal glucocorticoid release, while extra-hypothalamic CRH plays a key role in stressor-triggered behaviors. Here we report that hypothalamus-specific Crh knockout mic...

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Detalles Bibliográficos
Autores principales:	Zhang, Rong, Asai, Masato, Mahoney, Carrie E, Joachim, Maria, Shen, Yuan, Gunner, Georgia, Majzoub, Joseph A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339066/ https://www.ncbi.nlm.nih.gov/pubmed/27595593 http://dx.doi.org/10.1038/mp.2016.136

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