Cargando…
The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome
Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of chromosome 21. DS affects multiple organs, but it invariably results in altered brain development and diverse degrees of intellectual disability. A large body of evidence has shown that synaptic deficits and memory im...
Autores principales: | Contestabile, Andrea, Magara, Salvatore, Cancedda, Laura |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339239/ https://www.ncbi.nlm.nih.gov/pubmed/28326014 http://dx.doi.org/10.3389/fncel.2017.00054 |
Ejemplares similares
-
Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives
por: Deidda, Gabriele, et al.
Publicado: (2014) -
Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome
por: Begenisic, Tatjana, et al.
Publicado: (2011) -
GABAergic Control of Neurite Outgrowth and Remodeling During Development and Adult Neurogenesis: General Rules and Differences in Diverse Systems
por: Sernagor, Evelyne, et al.
Publicado: (2010) -
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
por: Pinto, Bruno, et al.
Publicado: (2020) -
Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome
por: Zorrilla de San Martin, Javier, et al.
Publicado: (2020)