Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern

Treatment with lipid-lowering drugs, statins, is common all over the world. Lately, the occurrence of spontaneous tendon ruptures or tendinosis have suggested a negative influence of statins upon tendon tissue. But how statins might influence tendons is not clear. In the present study, we investigat...

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Detalles Bibliográficos
Autores principales: Eliasson, Pernilla, Svensson, Rene B., Giannopoulos, Antonis, Eismark, Christian, Kjær, Michael, Schjerling, Peter, Heinemeier, Katja M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339395/
https://www.ncbi.nlm.nih.gov/pubmed/28264197
http://dx.doi.org/10.1371/journal.pone.0172797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339395/
https://www.ncbi.nlm.nih.gov/pubmed/28264197
http://dx.doi.org/10.1371/journal.pone.0172797

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