Cargando…

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants()

The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric Keap1 functions as the Cullin3 adaptor, and importantly, it is also the critical component of the E3 ligase that performs...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinkova-Kostova, Albena T., Kostov, Rumen V., Canning, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339396/
https://www.ncbi.nlm.nih.gov/pubmed/27497696
http://dx.doi.org/10.1016/j.abb.2016.08.005