Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Large conductance Ca(2+)-activated K(+) channels (BK channels) gate open in response to both membrane voltage and intracellular Ca(2+). The channel is formed by a central pore-gate domain (PGD), which spans the membrane, plus transmembrane voltage sensors and a cytoplasmic gating ring that acts as a...

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Detalles Bibliográficos
Autores principales: Zhang, Guohui, Geng, Yanyan, Jin, Yakang, Shi, Jingyi, McFarland, Kelli, Magleby, Karl L., Salkoff, Lawrence, Cui, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339509/
https://www.ncbi.nlm.nih.gov/pubmed/28196879
http://dx.doi.org/10.1085/jgp.201611646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339509/
https://www.ncbi.nlm.nih.gov/pubmed/28196879
http://dx.doi.org/10.1085/jgp.201611646

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