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Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Large conductance Ca(2+)-activated K(+) channels (BK channels) gate open in response to both membrane voltage and intracellular Ca(2+). The channel is formed by a central pore-gate domain (PGD), which spans the membrane, plus transmembrane voltage sensors and a cytoplasmic gating ring that acts as a...

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Detalles Bibliográficos
Autores principales:	Zhang, Guohui, Geng, Yanyan, Jin, Yakang, Shi, Jingyi, McFarland, Kelli, Magleby, Karl L., Salkoff, Lawrence, Cui, Jianmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339509/ https://www.ncbi.nlm.nih.gov/pubmed/28196879 http://dx.doi.org/10.1085/jgp.201611646

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