Cargando…

The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells

Rhabdomyosarcoma (RMS), the most common cancer of connective tissues in pediatrics, is often resistant to conventional therapies. One underlying mechanism of this resistance is the overexpression of Inhibitor of Apoptosis (IAP) proteins, leading to a dysfunctional cell death program within tumor cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fischer, Kyra, Tognarelli, Sara, Roesler, Stefanie, Boedicker, Cathinka, Schubert, Ralf, Steinle, Alexander, Klingebiel, Thomas, Bader, Peter, Fulda, Simone, Ullrich, Evelyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339542/ https://www.ncbi.nlm.nih.gov/pubmed/28326081 http://dx.doi.org/10.3389/fimmu.2017.00202

Ejemplares similares

Characterization of BV6-Induced Sensitization to the NK Cell Killing of Pediatric Rhabdomyosarcoma Spheroids
por: Särchen, Vinzenz, et al.
Publicado: (2023)

Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells
por: Erdogdu, Ufuk, et al.
Publicado: (2021)

SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy
por: Rettinger, Eva, et al.
Publicado: (2014)

Redox regulation of Smac mimetic-induced cell death
por: Fulda, Simone
Publicado: (2015)

Regulation of cancer stem-like cell differentiation by Smac mimetics
por: Fulda, Simone
Publicado: (2014)

The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis
por: Hehlgans, Stephanie, et al.
Publicado: (2015)

SMAC Mimetic BV6 Induces Cell Death in Monocytes and Maturation of Monocyte-Derived Dendritic Cells
por: Müller-Sienerth, Nicole, et al.
Publicado: (2011)

Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells
por: Roesler, Stefanie, et al.
Publicado: (2016)

The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells
por: Hannes, Sabine, et al.
Publicado: (2021)

Co-targeting MCL-1 and ERK1/2 kinase induces mitochondrial apoptosis in rhabdomyosarcoma cells
por: Winkler, Marius, et al.
Publicado: (2021)

Smac mimetic-induced upregulation of interferon-β sensitizes glioblastoma to temozolomide-induced cell death
por: Marschall, V, et al.
Publicado: (2015)

Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells
por: Czaplinski, Sebastian, et al.
Publicado: (2015)

Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model
por: Dobson, Christine C, et al.
Publicado: (2016)

Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner()
por: Lindemann, Carina, et al.
Publicado: (2015)

Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells
por: Beug, Shawn T, et al.
Publicado: (2014)

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
por: Beug, Shawn T., et al.
Publicado: (2019)

RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death
por: Dächert, Jasmin, et al.
Publicado: (2016)

Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic
por: Balakrishnan, Kumudha, et al.
Publicado: (2016)

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines
por: Koch, Annkathrin, et al.
Publicado: (2021)

SMAC Mimetic BV6 Co-Treatment Downregulates the Factors Involved in Resistance and Relapse of Cancer: IAPs and Autophagy
por: Rafat, Sahar, et al.
Publicado: (2022)

Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy
por: Särchen, Vinzenz, et al.
Publicado: (2022)

The role of SMAC mimetics in regulation of tumor cell death and immunity
por: Emeagi, Perpetua U., et al.
Publicado: (2012)

Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
por: Steinhart, L, et al.
Publicado: (2013)

NK Cell Subgroups, Phenotype, and Functions After Autologous Stem Cell Transplantation
por: Jacobs, Benedikt, et al.
Publicado: (2015)

Future Therapeutic Directions for Smac-Mimetics
por: Morrish, Emma, et al.
Publicado: (2020)

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
por: Abhari, Behnaz Ahangarian, et al.
Publicado: (2019)

New light on Smac mimetics and breast cancer
por: Cornmark, L, et al.
Publicado: (2016)

Hyperosmotic stress enhances cytotoxicity of SMAC mimetics
por: Bittner, Sebastian, et al.
Publicado: (2017)

SMAC Mimetics as Therapeutic Agents in HIV Infection
por: Molyer, Bengisu, et al.
Publicado: (2021)

Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response
por: Eckhardt, I, et al.
Publicado: (2014)

Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis
por: Cristofanon, S, et al.
Publicado: (2015)

Correction: Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
por: Abhari, Behnaz Ahangarian, et al.
Publicado: (2020)

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells
por: Tchoghandjian, A, et al.
Publicado: (2013)

Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
por: Li, Bao-Xia, et al.
Publicado: (2018)

CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells
por: Campbell, Grant R., et al.
Publicado: (2021)

Redirecting neutrophils against bladder cancer cells by BCG and Smac mimetic combination
por: Jinesh G., Goodwin, et al.
Publicado: (2012)

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant
por: Fichtner, Michael, et al.
Publicado: (2020)

Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis
por: Eckhardt, I, et al.
Publicado: (2013)

Smac-mimetics reduce numbers and viability of human osteoclasts
por: Moen, Ingrid Nyhus, et al.
Publicado: (2021)

Correction to: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway
por: Li, Bao-Xia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_eq5j2q2lik0mff89s5g2n6ej6d