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Early Origin and Evolution of the Angelman Syndrome Ubiquitin Ligase Gene Ube3a
The human Ube3a gene encodes an E3 ubiquitin ligase and exhibits brain-specific genomic imprinting. Genetic abnormalities that affect the maternal copy of this gene cause the neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe mental retardation, speech impairment, s...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339648/ https://www.ncbi.nlm.nih.gov/pubmed/28326016 http://dx.doi.org/10.3389/fncel.2017.00062 |