Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness

Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology. Here, we analyze mice with a hypermorphic Zap70 mutation, W131A, which destabilizes the autoinhibitor...

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Detalles Bibliográficos
Autores principales: Hsu, Lih-Yun, Cheng, Debra A., Chen, Yiling, Liang, Hong-Erh, Weiss, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339679/
https://www.ncbi.nlm.nih.gov/pubmed/28159798
http://dx.doi.org/10.1084/jem.20161575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339679/
https://www.ncbi.nlm.nih.gov/pubmed/28159798
http://dx.doi.org/10.1084/jem.20161575

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