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Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity
Maintaining stemness of leukemic stem cells (LSCs) and reciprocal interactions between leukemia and stromal cells support leukemic progression and resistance to chemotherapy. Targeting the niche-based microenvironment is thus a new approach for leukemia therapy. Cordycepin is an analogue of adenosin...
Autores principales: | Liang, Shu-Man, Lu, Yi-Jhu, Ko, Bor-Sheng, Jan, Yee-Jee, Shyue, Song-Kun, Yet, Shaw-Fang, Liou, Jun-Yang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339716/ https://www.ncbi.nlm.nih.gov/pubmed/28266575 http://dx.doi.org/10.1038/srep43930 |
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