The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA

Toll-like Receptor 9 (TLR9) is an innate immune receptor recognizing microbial DNA. TLR9 is also activated by self-derived DNA, such as mitochondrial DNA, in a variety of inflammatory diseases. We show here that TLR9 activation in vivo is controlled by an anti-TLR9 monoclonal Ab (mAb). A newly estab...

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Detalles Bibliográficos
Autores principales: Murakami, Yusuke, Fukui, Ryutaro, Motoi, Yuji, Shibata, Takuma, Saitoh, Shin-Ichiroh, Sato, Ryota, Miyake, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339793/
https://www.ncbi.nlm.nih.gov/pubmed/28266597
http://dx.doi.org/10.1038/srep44042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339793/
https://www.ncbi.nlm.nih.gov/pubmed/28266597
http://dx.doi.org/10.1038/srep44042

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